منابع مشابه
Orexin receptor-1 mediates brown fat developmental differentiation
Orexin A (OX) is a small excitatory neuropeptide hormone that stimulates feeding, wakefulness and energy expenditure via a pair of G-coupled protein receptors, namely orexin receptor-1 (OXR1) and orexin receptor-2 (OXR2). OX-deficient mice are sensitive to obesity despite being hypophagic. The obesogenic effect of OX-deletion is due to brown adipose tissue (BAT) dysfunction, a defect that origi...
متن کاملOrexin modulates brown adipose tissue thermogenesis.
Non-shivering thermogenesis in brown adipose tissue (BAT) plays an important role in thermoregulation. In addition, activations of BAT have important implications for energy homeostasis due to the metabolic consumption of energy reserves entailed in the production of heat in this tissue. In this conceptual overview we describe the role of orexins/hypocretins within the central nervous system in...
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The transcriptional coactivator PGC-1alpha promotes mitochondrial biogenesis and thermogenic programs in brown adipose tissue. Pan et al. (2009) identify the transcription factor twist-1 as a negative feedback regulator of PGC-1alpha.
متن کاملWhither brown fat?
In 1551 Gessner described a lobular fatty tissue which we now know as brown adipose tissue (BAT). Apart from a few descriptions of the tissue in hibernators, it was then virtually ignored by scientists for the next four hundred years until its involvement in the thermoregulation of non-hibernating mammals was suggested (Smith, 1961). However, even after this work in the early 1960s, doubts over...
متن کاملBrown fat and thermogenesis.
Historical Background. ..................................................... 330 PhylogeneticDistribution .................................................. 332 AnatomyandTopology ................................................... 333 Vasculature of Brown Adipose Tissue. ...................................... 338 Microcirculation and vascularity .......................................... 338 G...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2011
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.2563